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KMID : 0605620050120020098
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Journal of Korean Society of Biological Psychiatry
2005 Volume.12 No. 2 p.98 ~ p.106
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The Change of K-MMSE Following Donepezil Medication in Patients with Alzheimer’s Disease and Small Vessel Dementia, and the Characteristics of Alzheimer’s Disease with Meaningful K-MMSE Change
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Kwak Yong-Tae
Han Il-Woo
Kim June
Lee Yu-Sang
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Abstract
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Objectives:Donepezil is a widely used drug for the treatment of patients with Alzheimer’s disease(AD). The aim of the present study was to clarify the efficacy and the characteristics of responders to donepezil.
methods:Patients with probable AD(n=80 ; 75.7 years) and small vessel dementia(SVD)(n=18 ; 77.8 years) who received donepezil were retrospectively analyzed using Alzheimer’s registry, and three questions were asked: 1) Does donepezil therapy improves cognitive symptoms in patients with dementia? 2) If donepezil improves cognitive symptoms, which items of the K-MMSE are improved? 3) What are the characteristics of responder to donepezil medication?
Results:1) After donepezil medication, cognitive function measured by the K-MMSE was significantly improved in both types of dementia(AD and SVD), However, statistical differences were not found between these groups. 2) In a clinical trial of donepezil, the patients performed better than before mediation on K-MMSE items assessing orientation, recall, construction, concentration, calculation. 3) In AD, the K-MMSE score before medication was closely related with response of donepezil.
Conclusion:This study suggests that donepezil improves various cognitive functions in both types of dementia, and the responsive group had significantly lower K-MMSE scores than the non-responsive group before medication.
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KEYWORD
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Donepezil, Alzheimer’s Disease, Small Vessel Dementia, K-MMSE, Responsive group
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